How TXA works?

• A. It inhibits plasmin formation, reducing fibrin degradation.
• B. It inhibits platelet aggregation.
• C. It promotes breakdown of fibrin clots.
• D. It is an antifibrinolytic that inhibits plasmin from breaking down fibrin clots.

Answer: (D)

TXA works by blocking fibrinolysis, the process that dissolves clots. It acts as an antifibrinolytic by binding to plasminogen and plasmin at sites that would normally attach to fibrin, preventing plasmin from binding to fibrin and from degrading it. This reduces plasmin activity on the clot, helping to stabilize the fibrin mesh and slow down clot breakdown. It does not inhibit platelet aggregation, nor does it promote clot dissolution; the most accurate description is that TXA inhibits plasmin from breaking down fibrin clots.